Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237830 | 0.85 | EGLN1 (0.49) | KCNH2HDAC3EGLN1HDAC2HDAC1 | |
| SCHEMBL4676740 | 0.84 | EGLN1 (0.48) | KCNH2HDAC3EGLN1HDAC2HDAC1 | |
| SCHEMBL3442195 | 0.78 | GPR119 (0.59) | KCNH2ADRB1HDAC3GPR119PLD1 | |
| SCHEMBL13118685 | 0.78 | ADRB1 (0.52) | ADRB1PLD1USP2ALDH1A1CYP1A2 | |
| SCHEMBL15244897 | 0.77 | KCNH2 (0.56) | KCNH2HDAC3GPR119PLD1CACNA1C | |
| SCHEMBL1199415 | 0.77 | PLD1 (0.60) | KCNH2GPR119PLD1CACNA1CASIC3 | |
| SCHEMBL15244966 | 0.77 | KCNH2 (0.56) | KCNH2HDAC3GPR119PLD1CACNA1C | |
| SCHEMBL12911540 | 0.75 | HDAC3 (0.58) | KCNH2HDAC3GPR119PLD1CACNA1C | |
| SCHEMBL6352142 | 0.74 | CHRNB2 (0.50) | ADRB1PLD1CYP3A4CYP2C9 | |
| SCHEMBL2382933 | 0.74 | CYP1A2 (0.56) | KCNH2ADRB1HDAC3PLD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |