Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 7/20 | 0.48 |
| ▸ | PRKCA | P17252 | 6/20 | 0.48 |
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | PRKCG | P05129 | 2/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680124 | 0.76 | PRKCA (0.47) | PRKCBPRKCAGSK3BPRKCGCCNE2 | |
| SCHEMBL2954257 | 0.67 | GSK3B (0.43) | PRKCBPRKCAGSK3BPRKCGCCNE2 | |
| SCHEMBL2946233 | 0.66 | PRKCA (0.51) | PRKCBPRKCAGSK3BPRKCGCCNE2 | |
| SCHEMBL5754952 | 0.66 | PRKCA (0.67) | PRKCBPRKCAGSK3BPRKCGCCNE2 | |
| SCHEMBL8161830 | 0.65 | CCNE2 (0.81) | PRKCBPRKCAGSK3BCCNE2CDK4 | |
| SCHEMBL7825912 | 0.64 | CDK2 (0.66) | PRKCBPRKCAGSK3BPRKCGCCNE2 | |
| SCHEMBL5686048 | 0.64 | CCNE2 (1.00) | PRKCAGSK3BCCNE2CDK4CCND1 | |
| SCHEMBL30319849 | 0.64 | CCNE2 (1.00) | PRKCAGSK3BCCNE2CDK4CCND1 | |
| SCHEMBL24622133 | 0.62 | CDK4 (0.74) | PRKCAGSK3BCCNE2CDK4CCND1 | |
| Acrylic Acid SCHEMBL5099069 | 0.62 | WDR5 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513520-B1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |