Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 14/20 | 0.67 |
| ▸ | GSK3B | P49841 | 13/20 | 0.67 |
| ▸ | PRKCB | P05771 | 13/20 | 0.67 |
| ▸ | PRKCG | P05129 | 10/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.48 |
| ▸ | PRKACA | P17612 | 3/20 | 0.48 |
| ▸ | PRKACG | P22612 | 3/20 | 0.48 |
| ▸ | PRKACB | P22694 | 3/20 | 0.48 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | PRKCH | P24723 | 3/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783076 | 0.90 | GSK3B (0.56) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL13013303 | 0.85 | PRKCA (0.63) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL3780543 | 0.82 | PRKCA (0.69) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL5758306 | 0.80 | GSK3B (1.00) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL5758075 | 0.79 | PRKCA (0.70) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL5759736 | 0.79 | PRKCA (0.70) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL5758532 | 0.75 | PRKCA (0.84) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL3771589 | 0.73 | PRKCA (0.84) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL5756702 | 0.73 | GSK3B (0.71) | PRKCAGSK3BPRKCBPRKCGPRKCD | |
| SCHEMBL3783864 | 0.70 | PRKCA (0.80) | PRKCAGSK3BPRKCBPRKCGPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |