Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675231 | 0.83 | LMNA (0.48) | KCNH2MRGPRX4MAPTRAB9AGPBAR1 | |
| SCHEMBL3564550 | 0.80 | MRGPRX4 (0.74) | KCNH2MRGPRX4GPBAR1PDE5APTGER4 | |
| SCHEMBL4672078 | 0.78 | PPARD (0.50) | KDM4EMAPTRAB9AFFAR1SMPD1 | |
| SCHEMBL4671564 | 0.76 | NPC1 (0.50) | KDM4EMAPTRAB9AGAAFFAR1 | |
| SCHEMBL377165 | 0.73 | KDM4E (0.44) | KDM4EMAPTLMNAHDAC6ALDH1A1 | |
| SCHEMBL14021653 | 0.71 | CYSLTR2 (0.62) | KCNH2FFAR1CYSLTR2CYSLTR1AKR1B1 | |
| SCHEMBL4671246 | 0.70 | PPARD (0.47) | MRGPRX4MAPTGAAPTGER4DHODH | |
| SCHEMBL11188667 | 0.70 | MRGPRX4 (0.78) | KCNH2MRGPRX4KDM4EGPBAR1PDE5A | |
| SCHEMBL3135703 | 0.70 | MCL1 (0.49) | RAB9AMCL1DHODHNPC1 | |
| SCHEMBL3554869 | 0.69 | RAB9A (0.52) | KDM4EMAPTRAB9AGAAGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | claimed |