Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 6/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | FAP | Q12884 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685664 | 0.91 | SMN1; SMN2 (0.44) | MEN1KMT2ASMN1; SMN2PSMB8PSMB5 | |
| SCHEMBL4739666 | 0.88 | MMP1 (0.43) | MEN1KMT2ASMN1; SMN2PSMB8PSMB5 | |
| Hydrochloric Acid SCHEMBL4679238 | 0.88 | CYP3A4 (0.43) | MEN1KMT2ASMN1; SMN2MMP1MMP13 | |
| SCHEMBL4680567 | 0.87 | CYP2D6 (0.45) | MEN1KMT2ASMN1; SMN2TSHRCYP2D6 | |
| SCHEMBL4678547 | 0.87 | CYP2D6 (0.43) | MEN1KMT2ASMN1; SMN2TSHRCYP2D6 | |
| Hydrochloric Acid SCHEMBL4683782 | 0.86 | CYP3A4 (0.43) | MEN1KMT2ASMN1; SMN2TSHRCYP2D6 | |
| Hydrochloric Acid SCHEMBL4683142 | 0.86 | MMP1 (0.44) | MEN1KMT2ASMN1; SMN2MMP1MMP13 | |
| Hydrochloric Acid SCHEMBL4685539 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2ASMN1; SMN2MMP1MMP13 | |
| Hydrochloric Acid SCHEMBL4685543 | 0.84 | ALDH1A1 (0.45) | MEN1KMT2ASMN1; SMN2MMP1MMP13 | |
| SCHEMBL4682805 | 0.83 | ALDH1A1 (0.50) | SMN1; SMN2MMP1MMP13GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |
| EP-1058680-A1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999043657-A1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-02 | — | — | WO | disclosed |