Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685664 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2MEN1KMT2ACYP2D6TSHR | |
| SCHEMBL4679440 | 0.88 | MEN1 (0.44) | MMP1MMP13SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4682805 | 0.85 | ALDH1A1 (0.50) | MMP1MMP13SMN1; SMN2GPR119LMNA | |
| SCHEMBL4680567 | 0.85 | CYP2D6 (0.45) | SMN1; SMN2MEN1KMT2ACYP2D6TSHR | |
| SCHEMBL4678547 | 0.85 | CYP2D6 (0.43) | SMN1; SMN2MEN1KMT2ACYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL4679238 | 0.84 | CYP3A4 (0.43) | MMP1MMP13SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4683142 | 0.84 | MMP1 (0.44) | MMP1MMP13SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4683782 | 0.84 | CYP3A4 (0.43) | SMN1; SMN2MEN1KMT2ACYP2D6TSHR | |
| SCHEMBL4682714 | 0.82 | ALDH1A1 (0.49) | MMP1MMP13SMN1; SMN2GPR119LMNA | |
| Hydrochloric Acid SCHEMBL4685539 | 0.81 | ALDH1A1 (0.45) | MMP1MMP13SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1058680-B1 | 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-09 | — | — | EP | disclosed |
| US-6319920-B1 | MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY | SYNTEX (U.S.A.) LLC | 2001-11-20 | — | — | US | disclosed |