SCHEMBL4682805

SCHEMBL4682805

CCN(CC1CCN(C(=O)OC(C)(C)C)CC1)C(C)Cc1ccc(OC)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
GPR119 Q8TDV5 1/20 0.50
BACE1 P56817 2/20 0.48
YAP1 P46937 3/20 0.47
STS P08842 1/20 0.46
MMP1 P03956 3/20 0.45
MMP3 P08254 3/20 0.45
MMP7 P09237 3/20 0.45
MMP9 P14780 3/20 0.45
MMP8 P22894 3/20 0.45
MMP13 P45452 3/20 0.45
MMP2 P08253 2/20 0.45
CTSD P07339 1/20 0.45
CTSE P14091 1/20 0.45
LMNA P02545 2/20 0.45
TGFBR1 P36897 1/20 0.45
BMP1 P13497 1/20 0.44
SLC2A1 P11166 1/20 0.44
TP53 P04637 1/20 0.44
EPHX2 P34913 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4682714 0.96 ALDH1A1 (0.49) ALDH1A1GPR119BACE1YAP1STS
SCHEMBL4680301 0.92 ALDH1A1 (0.48) ALDH1A1GPR119BACE1YAP1STS
Water SCHEMBL4677873 0.87 YAP1 (0.43) ALDH1A1GPR119BACE1YAP1MMP1
SCHEMBL4678547 0.86 CYP2D6 (0.43) ALDH1A1LMNASMN1; SMN2
SCHEMBL4680567 0.86 CYP2D6 (0.45) ALDH1A1LMNASMN1; SMN2
SCHEMBL4739666 0.85 MMP1 (0.43) ALDH1A1GPR119MMP1MMP3MMP7
Water SCHEMBL4677879 0.85 YAP1 (0.44) ALDH1A1GPR119BACE1YAP1MMP1
Hydrochloric Acid SCHEMBL4679238 0.85 CYP3A4 (0.43) ALDH1A1MMP1MMP3MMP7MMP13
Hydrochloric Acid SCHEMBL4683782 0.85 CYP3A4 (0.43) ALDH1A1LMNASMN1; SMN2
Hydrochloric Acid SCHEMBL4683142 0.85 MMP1 (0.44) ALDH1A1MMP1MMP3MMP7MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1058680-B1 2-ARYLETHYL-(PIPERIDIN-4-YLMETHYL)AMINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS HOFFMANN LA ROCHE (CH) 2008-07-09 EP disclosed
US-6319920-B1 MUSCARINIC RECEPTOR ANTAGONIST USED IN GASTROINTESTINAL, GENITOURINARY TRACT, RESPIRATORY TRACT, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM DISORDERS AND IN ANESTHESIOLOGY AND OPHTHALMOLOGY SYNTEX (U.S.A.) LLC 2001-11-20 US disclosed