Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20091675 | 0.80 | ALDH1A1 (0.43) | KMT2ATDP1HTTALDH1A1RECQL | |
| SCHEMBL26122242 | 0.79 | CYP19A1 (0.35) | KMT2ATDP1ALDH1A1RECQLSMN1; SMN2 | |
| SCHEMBL20155932 | 0.77 | RECQL (0.41) | KMT2AHTTALDH1A1RECQLLMNA | |
| SCHEMBL20073210 | 0.76 | POLB (0.38) | TDP1RECQLLMNAPOLB | |
| SCHEMBL24498552 | 0.76 | ALDH1A1 (0.35) | KMT2ATDP1HTTALDH1A1RECQL | |
| SCHEMBL27540668 | 0.75 | ALB (0.47) | KMT2ATDP1HTTALDH1A1ACLY | |
| SCHEMBL26120002 | 0.73 | PKM (0.42) | KMT2ATDP1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL26119628 | 0.73 | KMT2A (0.42) | KMT2ATDP1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL23042975 | 0.71 | ALDH1A1 (0.40) | KMT2ATDP1HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL30783964 | 0.69 | PKM (0.42) | KMT2ATDP1HTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654232-A4 | SULFONYL SUBSTITUTED N-(BIARYLMETHYL) AMINOCYCLOPROPANECARBOXAMIDES | MERCK & CO INC (US) | 2008-11-12 | — | — | EP | disclosed |
| US-7332499-B2 | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides | MERCK & CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-20060247229-A1 | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides | MERCK SHARP & DOHME CORP. | 2006-11-02 | — | — | US | disclosed |
| EP-1654232-A1 | SULFONYL SUBSTITUTED N-(BIARYLMETHYL) AMINOCYCLOPROPANECARBOXAMIDES | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016886-A1 | SULFONYL SUBSTITUTED N-(BIARYLMETHYL) AMINOCYCLOPROPANECARBOXAMIDES | MERCK & CO., INC. (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247229-A1 | Sulfonyl substituted n-(biarylmethyl) aminocyclopropanecarboxamides | BDKRB1, BDKRB2, CNR2 | KMT2A 2522/4885TDP1 4450/4885HTT 3172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.