Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 4/20 | 0.64 |
| ▸ | QPCT | Q16769 | 2/20 | 0.61 |
| ▸ | PRKCB | P05771 | 4/20 | 0.61 |
| ▸ | PRKCG | P05129 | 1/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | PRKACA | P17612 | 1/20 | 0.54 |
| ▸ | PRKACG | P22612 | 1/20 | 0.54 |
| ▸ | PRKACB | P22694 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 1/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682947 | 0.82 | GSK3B (0.62) | GSK3BKDRFLT3QPCTPRKCB | |
| SCHEMBL4680883 | 0.80 | GSK3B (0.63) | GSK3BKDRFLT3QPCTPRKCB | |
| SCHEMBL7873644 | 0.79 | PRKACA (0.80) | GSK3BKDRFLT3PRKCBPRKCA | |
| SCHEMBL9955401 | 0.78 | GSK3B (1.00) | GSK3BKDRFLT3QPCTCDK4 | |
| SCHEMBL14522482 | 0.76 | GSK3B (0.69) | GSK3BKDRFLT3PRKCBPRKCA | |
| SCHEMBL4683228 | 0.76 | GSK3B (0.58) | GSK3BKDRFLT3QPCTPRKCB | |
| SCHEMBL3139598 | 0.76 | GSK3B (0.78) | GSK3BPRKCBPRKCGPRKCAPRKCE | |
| SCHEMBL2982584 | 0.76 | GSK3B (1.00) | GSK3BPRKCBPRKCGPRKCACCNB2 | |
| SCHEMBL12607875 | 0.75 | KDR (1.00) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL3150613 | 0.75 | PIM1 (0.77) | GSK3BPRKCBPRKCGPRKCAPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513520-B1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |