Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.62 |
| ▸ | KDR | P35968 | 5/20 | 0.62 |
| ▸ | FLT3 | P36888 | 4/20 | 0.61 |
| ▸ | QPCT | Q16769 | 2/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.58 |
| ▸ | PRKCB | P05771 | 3/20 | 0.57 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | PRKACG | P22612 | 2/20 | 0.56 |
| ▸ | PRKACB | P22694 | 2/20 | 0.56 |
| ▸ | PRKCA | P17252 | 3/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | PRKCH | P24723 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682950 | 0.82 | GSK3B (0.64) | GSK3BKDRFLT3QPCTCCNB2 | |
| SCHEMBL4680883 | 0.79 | GSK3B (0.63) | GSK3BKDRFLT3QPCTPRKCB | |
| SCHEMBL14522482 | 0.77 | GSK3B (0.69) | GSK3BKDRFLT3CCNB2CDK1 | |
| SCHEMBL12506836 | 0.77 | GSK3B (1.00) | GSK3BKDRFLT3QPCTPRKCB | |
| SCHEMBL12607875 | 0.76 | KDR (1.00) | GSK3BKDRFLT3QPCTPRKCA | |
| SCHEMBL4683218 | 0.76 | GSK3B (0.55) | GSK3BKDRFLT3QPCTCCNB2 | |
| SCHEMBL4683228 | 0.75 | GSK3B (0.58) | GSK3BKDRFLT3QPCTPRKCB | |
| SCHEMBL7873644 | 0.75 | PRKACA (0.80) | GSK3BKDRFLT3CCNB2CDK1 | |
| SCHEMBL9955401 | 0.74 | GSK3B (1.00) | GSK3BKDRFLT3QPCTPRKACA | |
| SCHEMBL8122815 | 0.74 | PRKCA (0.87) | GSK3BKDRCCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513520-B1 | SUBSTITUTED PYRROLINES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |