Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.82 |
| ▸ | ITGA2B | P08514 | 16/20 | 0.82 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7293550 | 0.91 | ITGB3 (0.68) | ITGB3ITGA2BCYP51A1F2PLG | |
| SCHEMBL7274759 | 0.91 | ITGB3 (0.68) | ITGB3ITGA2BCYP51A1F2PLG | |
| Lamifiban SCHEMBL4683 | 0.90 | ITGB3 (1.00) | ITGB3ITGA2BCYP51A1F2PRSS1 | |
| Lamifiban SCHEMBL871446 | 0.90 | ITGB3 (1.00) | ITGB3ITGA2BCYP51A1F2PRSS1 | |
| SCHEMBL8881333 | 0.89 | ITGB3 (0.65) | ITGB3ITGA2B | |
| SCHEMBL8690141 | 0.87 | ITGB3 (0.62) | ITGB3ITGA2BCYP51A1CCKBRF2 | |
| SCHEMBL7274714 | 0.84 | ITGB3 (0.80) | ITGB3ITGA2B | |
| SCHEMBL7159286 | 0.84 | ITGB3 (0.83) | ITGB3ITGA2BF2PRSS1PLG | |
| SCHEMBL7282972 | 0.83 | ITGB3 (0.86) | ITGB3ITGA2BF2PRSS1 | |
| SCHEMBL7284586 | 0.83 | ITGB3 (0.82) | ITGB3ITGA2BCYP51A1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658928-A | ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS,WOUND HEALING AGENTS, OSTEOPOROSIS | HOFFMANN-LA ROCHE INC. (US) | 1997-08-19 | — | — | US | claimed |
| EP-0505868-B1 | N-Acyl-alpha-aminoacids derivatives | HOFFMANN LA ROCHE (CH) | 1995-09-13 | — | — | EP | claimed |
| EP-0505868-A2 | N-Acyl-alpha-aminoacids derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-09-30 | — | — | EP | claimed |
| US-5658928-A | ANTICOAGULANTS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS,WOUND HEALING AGENTS, OSTEOPOROSIS | HOFFMANN-LA ROCHE INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5545658-A | FOR TREATMENT OR PROPHYLAXIS OF ILLNESSES WHICH ARE CAUSED BY THE BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELETS AND BY BLOOD PLATELET AGGREGATION AND CELL-CELL ADHESION | HOFFMAN-LA ROCHE INC. (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0505868-B1 | N-Acyl-alpha-aminoacids derivatives | HOFFMANN LA ROCHE (CH) | 1995-09-13 | — | — | EP | disclosed |
| US-5378712-A | Antithrombosis | Hoffmann-La Roche Inc (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0505868-A2 | N-Acyl-alpha-aminoacids derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-09-30 | — | — | EP | disclosed |