Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694021 | 0.78 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5266049 | 0.77 | RAB9A (0.60) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL13113988 | 0.76 | RAB9A (0.54) | RAB9ANPC1IDO1SMN1; SMN2KCNH2 | |
| SCHEMBL13804814 | 0.75 | FDFT1 (0.62) | RAB9ANPC1FDFT1 | |
| SCHEMBL3525023 | 0.75 | FDFT1 (0.62) | RAB9ANPC1FDFT1 | |
| SCHEMBL4694805 | 0.74 | KMT2A (0.44) | RAB9AHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5201159 | 0.74 | PKM (0.48) | RAB9ANPC1HPGDSMN1; SMN2GAA | |
| SCHEMBL5200358 | 0.74 | SMN1; SMN2 (0.41) | RAB9ANPC1HPGDSMN1; SMN2GAA | |
| SCHEMBL4688373 | 0.74 | HSD17B10 (0.46) | GAAKCNH2ALDH1A1 | |
| SCHEMBL5262774 | 0.74 | SLC6A9 (0.54) | RAB9ANPC1SMN1; SMN2GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496838-A4 | SUBSTITUTED AMIDES | MERCK & CO INC (US) | 2008-07-02 | — | — | EP | claimed |
| EP-1496838-A2 | SUBSTITUTED AMIDES | Merck & Co., Inc. (US) | 2005-01-19 | — | — | EP | claimed |
| WO-2003077847-A2 | SUBSTITUTED AMIDES | MERCK & CO., INC. (US) | 2003-09-25 | — | — | WO | claimed |