Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689070 | 0.88 | GABRA1 (0.48) | MTNR1AMTNR1BGPR84HTR2ANR4A2 | |
| SCHEMBL3952651 | 0.87 | KDM4E (0.51) | TSHRMTNR1AMTNR1BGPR84HSD17B10 | |
| SCHEMBL3952650 | 0.87 | KDM4E (0.51) | TSHRMTNR1AMTNR1BGPR84HSD17B10 | |
| SCHEMBL4688784 | 0.87 | SCN9A (0.44) | MTNR1AMTNR1BHSD17B10SCN9ATRPM8 | |
| SCHEMBL3949134 | 0.84 | TRPV1 (0.44) | MTNR1ASCN9ATRPM8 | |
| SCHEMBL4688421 | 0.82 | LTA4H (0.43) | MTNR1AMTNR1BHTR2ASCN9ATRPM8 | |
| SCHEMBL4038258 | 0.81 | SCN9A (0.40) | MTNR1AMTNR1BSCN9ATRPM8 | |
| SCHEMBL4686398 | 0.81 | TSHR (0.50) | TSHRMTNR1AMTNR1BGPR84GFER | |
| SCHEMBL3019423 | 0.78 | GPR84 (0.44) | TSHRGPR84HTR2ANR4A2 | |
| SCHEMBL9257193 | 0.76 | GPR84 (0.55) | TSHRMTNR1AMTNR1BGPR84GFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996592-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | Nycomed GmbH (DE) | 2008-12-03 | — | — | EP | disclosed |
| EP-1994033-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007096393-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007096395-A1 | INDOLOPYRIDINES AS EG5 KINESIN MODULATORS | 4SC AG (DE) | 2007-08-30 | — | — | WO | disclosed |