Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694453 | 0.79 | S1PR1 (0.38) | SMN1; SMN2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL3966605 | 0.75 | KMT2A (0.39) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL4695774 | 0.67 | TLR8 (0.47) | ALDH1A1CYP3A4HTTKMT2AMAPT | |
| SCHEMBL4689649 | 0.65 | TLR8 (0.49) | — | |
| SCHEMBL4693224 | 0.63 | S1PR1 (0.43) | LMNAL3MBTL1ALDH1A1KDM4ECYP1A2 | |
| SCHEMBL10942661 | 0.62 | F2R (0.53) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL10947738 | 0.62 | F2R (0.53) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL13178829 | 0.61 | PTPN1 (0.68) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL13129145 | 0.61 | PTPN1 (0.45) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL19116495 | 0.61 | ALDH1A1 (0.66) | SMN1; SMN2NPC1RAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |