Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966666 | 0.90 | L3MBTL1 (0.36) | SOAT1ATMRAB9ANPC1HTT | |
| SCHEMBL3967355 | 0.86 | L3MBTL1 (0.39) | ATMRAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL4691170 | 0.83 | AR (0.40) | S1PR1SOAT1ALOX5SMN1; SMN2MEN1 | |
| SCHEMBL4693224 | 0.83 | S1PR1 (0.43) | S1PR1SOAT1ALOX5L3MBTL1CYP2C9 | |
| SCHEMBL4689750 | 0.79 | SMN1; SMN2 (0.45) | ATMRAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL3965245 | 0.75 | HTT (0.42) | ATMRAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL3926799 | 0.72 | ATM (0.37) | ATMRAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL8325829 | 0.72 | CNR2 (0.47) | SOAT1RAB9ANPC1HTTSMN1; SMN2 | |
| SCHEMBL3964910 | 0.68 | ADORA1 (0.43) | RAB9ANPC1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL21120072 | 0.67 | GLS (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |