Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694453 | 0.83 | S1PR1 (0.38) | S1PR1SOAT1ALDH1A1L3MBTL1CYP2C9 | |
| SCHEMBL4691170 | 0.80 | AR (0.40) | S1PR1SOAT1ALDH1A1KDM4ETP53 | |
| SCHEMBL3963194 | 0.74 | L3MBTL1 (0.38) | LMNAALDH1A1L3MBTL1CYP1A2POLB | |
| SCHEMBL3966666 | 0.73 | L3MBTL1 (0.36) | LMNASOAT1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL4689066 | 0.71 | TLR8 (0.44) | — | |
| SCHEMBL3967355 | 0.68 | L3MBTL1 (0.39) | LMNAALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL8325829 | 0.67 | CNR2 (0.47) | SOAT1L3MBTL1MAPTCNR1CNR2 | |
| SCHEMBL28481299 | 0.65 | PTGS2 (0.37) | TP53CYP3A4MAPTALOX15TSHR | |
| SCHEMBL21120072 | 0.64 | GLS (0.50) | — | |
| SCHEMBL4689750 | 0.63 | SMN1; SMN2 (0.45) | LMNAALDH1A1L3MBTL1CYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |