Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 14/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 13/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 13/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692140 | 0.84 | ITGAL (0.38) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4692248 | 0.79 | ALOX5 (0.47) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4690047 | 0.73 | ITGAL (0.40) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4687837 | 0.73 | ITGAL (0.40) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4687956 | 0.72 | ALOX5 (0.50) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4690051 | 0.70 | ALOX5 (0.46) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4693030 | 0.68 | GAA (0.39) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL4687618 | 0.65 | ITGB2 (0.41) | ITGALITGB2ICAM1ALOX5CES2 | |
| SCHEMBL22898546 | 0.64 | RAB9A (0.58) | ITGALITGB2ICAM1 | |
| SCHEMBL4689811 | 0.63 | ALOX5 (0.46) | ITGALITGB2ICAM1POLBALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399155-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2008-05-28 | — | — | EP | claimed |