Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 6/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CCL5 | P13501 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283594 | 0.86 | CCL5 (0.43) | CCR5CCL5 | |
| SCHEMBL3281863 | 0.85 | HCRTR1 (0.48) | HCRTR1HCRTR2TNFCCR5 | |
| SCHEMBL4690403 | 0.85 | HCRTR1 (0.39) | HCRTR1HCRTR2TNFCCR5HRH4 | |
| SCHEMBL4694334 | 0.85 | HCRTR1 (0.43) | HCRTR1HCRTR2EPHX2TNFCCR5 | |
| SCHEMBL4695961 | 0.85 | HCRTR1 (0.36) | HCRTR1HCRTR2MAPTTNFCCR5 | |
| SCHEMBL3282223 | 0.85 | CCR5 (0.43) | HCRTR1HCRTR2CCR5CCL5 | |
| SCHEMBL4694265 | 0.84 | HCRTR1 (0.38) | HCRTR1HCRTR2FPR2PROKR1TNF | |
| SCHEMBL5659102 | 0.84 | CCR5 (0.45) | HCRTR1HCRTR2TNFCCR5HRH4 | |
| SCHEMBL4691534 | 0.84 | GFER (0.43) | HCRTR1HCRTR2CCR5 | |
| SCHEMBL4693896 | 0.83 | HCRTR1 (0.47) | HCRTR1HCRTR2MAPTTNFCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |