Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 9/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CCL5 | P13501 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283596 | 0.86 | CCL5 (0.49) | CCR5CCL5KCNH2 | |
| SCHEMBL4690123 | 0.86 | MAPT (0.49) | MAPTSMN1; SMN2LMNAKCNH2ALDH1A1 | |
| SCHEMBL4695962 | 0.85 | MEN1 (0.41) | MAPTGAASMN1; SMN2CCR5LMNA | |
| SCHEMBL3281865 | 0.85 | CCR5 (0.52) | MAPTGAASMN1; SMN2CCR5LMNA | |
| SCHEMBL4694337 | 0.85 | CCR5 (0.43) | MAPTGAASMN1; SMN2CCR5LMNA | |
| SCHEMBL4690404 | 0.85 | CCR5 (0.41) | MAPTGAASMN1; SMN2CCR5LMNA | |
| SCHEMBL3282227 | 0.85 | CCR5 (0.51) | CCR5LMNACCL5KCNH2 | |
| SCHEMBL4694268 | 0.85 | POLB (0.45) | MAPTGAASMN1; SMN2KDM4ECCR5 | |
| SCHEMBL4690482 | 0.85 | CCR5 (0.43) | MAPTGAASMN1; SMN2KDM4ECCR5 | |
| SCHEMBL5659108 | 0.84 | CCR5 (0.53) | MAPTGAASMN1; SMN2CCR5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |