Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3283591 | 0.86 | CCL5 (0.51) | KCNH2 | |
| SCHEMBL4690129 | 0.86 | MAPT (0.45) | MAPTSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL4695960 | 0.85 | ALDH1A1 (0.46) | MAPTTP53HPGDSMN1; SMN2LMNA | |
| SCHEMBL4690401 | 0.85 | TP53 (0.47) | MAPTTP53HPGDSMN1; SMN2LMNA | |
| SCHEMBL3281859 | 0.85 | CCR5 (0.52) | TP53HPGDSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4694331 | 0.85 | TP53 (0.47) | MAPTTP53HPGDSMN1; SMN2LMNA | |
| SCHEMBL3282221 | 0.85 | CCR5 (0.51) | MAPTTP53SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4694262 | 0.85 | SMN1; SMN2 (0.48) | MAPTTP53SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4701550 | 0.84 | CCR5 (0.53) | MAPTTP53SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL4691529 | 0.84 | ALDH1A1 (0.51) | MAPTTP53SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |