Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692970 | 0.88 | CRHR1 (0.68) | CRHR1CRHR2MPOXDH | |
| SCHEMBL3965264 | 0.81 | CRHR1 (0.78) | CRHR1CRHR2HTR6DPP4 | |
| SCHEMBL3964426 | 0.80 | CRHR1 (0.47) | CRHR1CRHR2DPP4HAVCR2ALDH1A1 | |
| SCHEMBL4695616 | 0.77 | CRHR1 (0.52) | CRHR1CRHR2MEN1ALDH1A1KMT2A | |
| SCHEMBL3965673 | 0.76 | CRHR1 (0.60) | CRHR1CRHR2TSHR | |
| SCHEMBL3966240 | 0.74 | CRHR1 (0.48) | CRHR1CRHR2DPP4MEN1ALDH1A1 | |
| SCHEMBL3966751 | 0.74 | CRHR1 (0.48) | CRHR1CRHR2DPP4MEN1ALDH1A1 | |
| SCHEMBL5216342 | 0.74 | CRHR1 (0.49) | CRHR1CRHR2 | |
| SCHEMBL3972191 | 0.73 | CRHR1 (0.47) | CRHR1CRHR2DPP4MEN1TSHR | |
| SCHEMBL3964509 | 0.73 | CRHR1 (0.47) | CRHR1CRHR2DPP4ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |