Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692970 | 0.81 | CRHR1 (0.68) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL3967448 | 0.78 | CRHR1 (0.51) | CRHR1CRHR2SMPD3 | |
| SCHEMBL4690130 | 0.77 | CRHR1 (0.52) | CRHR1CRHR2MEN1ALDH1A1KMT2A | |
| SCHEMBL3965431 | 0.76 | CRHR1 (0.53) | CRHR1CRHR2MAPTPDE10ASMPD3 | |
| SCHEMBL3965673 | 0.75 | CRHR1 (0.60) | CRHR1CRHR2KDM4ESMPD3 | |
| SCHEMBL3966546 | 0.75 | CRHR1 (0.52) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL5216342 | 0.73 | CRHR1 (0.49) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3968860 | 0.73 | CRHR1 (0.52) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3965762 | 0.72 | CRHR1 (0.49) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3967414 | 0.72 | CRHR1 (0.52) | CRHR1CRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |