Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.68 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | MPO | P05164 | 3/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690130 | 0.88 | CRHR1 (0.52) | CRHR1CRHR2MPOXDH | |
| SCHEMBL4695616 | 0.81 | CRHR1 (0.52) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL3967632 | 0.81 | CRHR1 (1.00) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL3967745 | 0.78 | CRHR1 (0.65) | CRHR1CRHR2GAASMPD3 | |
| SCHEMBL3965673 | 0.76 | CRHR1 (0.60) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3970579 | 0.74 | CRHR1 (0.87) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL3965003 | 0.74 | CRHR1 (0.60) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL3962744 | 0.74 | CRHR1 (0.60) | CRHR1CRHR2PDE10ASMPD3 | |
| SCHEMBL5216342 | 0.74 | CRHR1 (0.49) | CRHR1CRHR2SMPD3 | |
| SCHEMBL3968095 | 0.73 | CRHR1 (0.59) | CRHR1CRHR2SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |