Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | XPO1 | O14980 | 1/20 | 0.33 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | LTK | P29376 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690166 | 0.76 | GABRA1 (0.37) | GABRA1GABRB2GLASTING1SLC11A2 | |
| SCHEMBL4619300 | 0.71 | GABRA1 (0.45) | GABRA1GABRB2ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7829502 | 0.69 | ALDH1A1 (0.39) | GABRA1GABRB2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4694392 | 0.69 | GABRA1 (0.40) | GABRA1GABRB2 | |
| SCHEMBL4690070 | 0.68 | GABRA1 (0.30) | GABRA1GABRB2 | |
| SCHEMBL28259937 | 0.68 | CYSLTR1 (0.43) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL3967537 | 0.68 | GAA (0.41) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL1701340 | 0.67 | GABRA1 (0.40) | GABRA1GABRB2ALDH1A1HSD17B10MEN1 | |
| SCHEMBL1759301 | 0.67 | PARP1 (0.40) | GABRA1GABRB2PIM1KDM4EALDH1A1 | |
| SCHEMBL28879956 | 0.66 | GABRA1 (0.43) | GABRA1GABRB2ALDH1A1HSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |