Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692752 | 0.86 | HTT (0.39) | MEN1LMNAKMT2AALDH1A1POLB | |
| SCHEMBL5232784 | 0.86 | CHRNB2 (0.43) | MEN1KMT2AALDH1A1SMN1; SMN2KCNH2 | |
| SCHEMBL5232761 | 0.85 | CCR5 (0.35) | LMNAALDH1A1KDM4ECCR5 | |
| SCHEMBL5235949 | 0.84 | KMT2A (0.34) | MEN1KMT2AALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL5235605 | 0.84 | ALDH1A1 (0.36) | ALDH1A1KDM4ECCR5GAA | |
| SCHEMBL5229109 | 0.84 | CHRNB2 (0.45) | LMNAALDH1A1POLBTSHRSMN1; SMN2 | |
| SCHEMBL5237723 | 0.83 | GRIN2B (0.39) | — | |
| SCHEMBL5236454 | 0.83 | GRIN2B (0.39) | — | |
| SCHEMBL5235726 | 0.82 | CCR5 (0.35) | MEN1KMT2AALDH1A1KDM4EHSD11B1 | |
| SCHEMBL5232619 | 0.82 | HSD11B1 (0.40) | KMT2AALDH1A1KDM4EHSD11B1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |