Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 10/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30100529 | 0.93 | KDM4E (0.58) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL31465181 | 0.84 | PARP1 (0.50) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30689750 | 0.83 | ALDH1A1 (0.50) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL1761171 | 0.82 | KDM4E (0.38) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1761183 | 0.82 | KDM4E (0.38) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL1761170 | 0.82 | KDM4E (0.38) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6383642 | 0.82 | ADRA1A (0.51) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL161548 | 0.82 | ADRA1A (0.51) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30666294 | 0.81 | KDM4E (0.39) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL30170745 | 0.81 | ADRA1A (0.50) | KDM4EMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-B1 | TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | EP | disclosed |