SCHEMBL4691637

SCHEMBL4691637

Cc1ccc(NC(=O)CCN2CC3CN(C(=O)c4ccoc4)CC3C2)cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 1/20 0.47
TP53 P04637 1/20 0.44
LMNA P02545 3/20 0.43
ALDH1A1 P00352 2/20 0.43
MAPK1 P28482 2/20 0.43
HPGD P15428 1/20 0.43
TSHR P16473 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
CHRNA4 P43681 1/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
UBE2M P61081 1/20 0.43
DCUN1D1 Q96GG9 1/20 0.43
MAPT P10636 2/20 0.42
KMT2A Q03164 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4695971 0.86 LMNA (0.50) TP53LMNAALDH1A1MAPK1HPGD
SCHEMBL4691642 0.85 CCR5 (0.47) CCR5LMNAALDH1A1CHRNB2CHRNB4
SCHEMBL4692723 0.84 CHRNB2 (0.47) TP53LMNACHRNB2CHRNB4CHRNA3
SCHEMBL4692068 0.83 ALDH1A1 (0.49) TP53LMNAALDH1A1MAPK1CYP2C9
SCHEMBL4694326 0.83 TP53 (0.44) TP53LMNAALDH1A1MAPK1HPGD
SCHEMBL4689516 0.83 MAPT (0.61) TP53LMNAALDH1A1MAPTKMT2A
SCHEMBL4690531 0.83 MAPT (0.48) TP53LMNAALDH1A1CYP2C9CYP2C19
SCHEMBL4691755 0.83 KMT2A (0.62) TP53LMNAALDH1A1MAPK1HPGD
SCHEMBL3281859 0.83 CCR5 (0.52) CCR5TP53LMNAALDH1A1MAPK1
SCHEMBL4690401 0.83 TP53 (0.47) TP53LMNAALDH1A1MAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP claimed
EP-1761542-A2 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2005121145-A2 OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2005-12-22 WO claimed
EP-1761542-B1 OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS HOFFMANN LA ROCHE (CH) 2008-01-02 EP disclosed