Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 6/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | UBE2M | P61081 | 2/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695974 | 0.91 | ALDH1A1 (0.43) | MAPTALDH1A1GAASMN1; SMN2AGTR1 | |
| SCHEMBL4691224 | 0.91 | UBE2M (0.45) | MAPTALDH1A1GAASMN1; SMN2AGTR1 | |
| SCHEMBL4692889 | 0.89 | MAPT (0.45) | MAPTALDH1A1GAASMN1; SMN2AGTR1 | |
| SCHEMBL4693334 | 0.89 | ALDH1A1 (0.45) | MAPTALDH1A1GAASMN1; SMN2AGTR1 | |
| SCHEMBL4693221 | 0.89 | CHRNB2 (0.45) | MAPTALDH1A1GAALMNAHTT | |
| SCHEMBL4693613 | 0.89 | GFER (0.49) | MAPTALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL4692075 | 0.89 | MAPT (0.43) | MAPTALDH1A1GAASMN1; SMN2AGTR1 | |
| SCHEMBL4690845 | 0.89 | NPY2R (0.46) | MAPTALDH1A1GAASMN1; SMN2AGTR1 | |
| SCHEMBL4689521 | 0.89 | MAPT (0.57) | MAPTALDH1A1UBE2MDCUN1D1LMNA | |
| SCHEMBL4690537 | 0.89 | ALDH1A1 (0.43) | MAPTALDH1A1GAASMN1; SMN2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |