Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 4/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 4/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 4/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694155 | 0.90 | NPY2R (0.48) | NPY2RALDH1A1MAPTLMNAHTT | |
| SCHEMBL4691224 | 0.90 | UBE2M (0.45) | UBE2MDCUN1D1ALDH1A1MAPTLMNA | |
| SCHEMBL4695974 | 0.90 | ALDH1A1 (0.43) | UBE2MDCUN1D1ALDH1A1MAPTLMNA | |
| SCHEMBL4695756 | 0.89 | RHOA (0.41) | NPY2RUBE2MDCUN1D1ALDH1A1MAPT | |
| SCHEMBL4691640 | 0.89 | MAPT (0.54) | UBE2MDCUN1D1ALDH1A1MAPTLMNA | |
| SCHEMBL4691883 | 0.88 | BRAF (0.41) | EPHX2UBE2MDCUN1D1ALDH1A1MAPT | |
| SCHEMBL4691230 | 0.88 | UBE2M (0.40) | UBE2MDCUN1D1ALDH1A1MAPTLMNA | |
| SCHEMBL4689521 | 0.87 | MAPT (0.57) | UBE2MDCUN1D1ALDH1A1MAPTLMNA | |
| SCHEMBL4692075 | 0.87 | MAPT (0.43) | UBE2MDCUN1D1ALDH1A1MAPTLMNA | |
| SCHEMBL4690537 | 0.87 | ALDH1A1 (0.43) | UBE2MDCUN1D1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |