Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CCL5 | P13501 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691441 | 0.89 | CCR5 (0.67) | LMNAUSP2CCR5KMT2ASMN1; SMN2 | |
| SCHEMBL4694462 | 0.88 | ALDH1A1 (0.60) | LMNAUSP2CCR5KMT2ASMN1; SMN2 | |
| SCHEMBL4695016 | 0.81 | CCL5 (0.53) | CCR5CCL5 | |
| SCHEMBL3285413 | 0.80 | CCR5 (0.70) | CCR5CCL5 | |
| SCHEMBL3290682 | 0.80 | CCR5 (0.70) | CCR5CCL5 | |
| SCHEMBL4691442 | 0.80 | CCL5 (0.56) | CCR5CCL5 | |
| SCHEMBL3282169 | 0.80 | CCL5 (0.69) | CCR5CCL5 | |
| SCHEMBL3290294 | 0.80 | CCL5 (0.69) | CCR5CCL5 | |
| SCHEMBL4691804 | 0.79 | CCR5 (0.47) | CCR5HCRTR1HCRTR2CCL5 | |
| SCHEMBL4691692 | 0.79 | CCR5 (0.47) | CCR5CCL5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |