Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695551 | 0.93 | CNR2 (0.40) | KDM4ELMNAPOLBHPGDCD274 | |
| SCHEMBL6027475 | 0.90 | TRPV1 (0.37) | KDM4ELMNAPOLBHPGDHTR1A | |
| SCHEMBL4695176 | 0.89 | POLB (0.37) | KDM4ELMNAPOLBHPGDALDH1A1 | |
| SCHEMBL4692631 | 0.89 | ALDH1A1 (0.35) | KDM4ELMNAPOLBHPGDMEN1 | |
| SCHEMBL4692560 | 0.85 | CD274 (0.39) | KDM4ECD274PDCD1 | |
| SCHEMBL6027362 | 0.84 | TRPV1 (0.39) | LMNACD274PDCD1ALDH1A1 | |
| SCHEMBL6027738 | 0.82 | ESRRG (0.40) | CD274PDCD1RAB9A | |
| SCHEMBL4694658 | 0.81 | ALDH1A1 (0.36) | LMNAHPGDCD274PDCD1MEN1 | |
| SCHEMBL5243396 | 0.80 | CHRM2 (0.39) | KDM4ELMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2639688 | 0.80 | POLB (0.44) | KDM4EPOLBCD274ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |