Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.35 |
| ▸ | LTA4H | P09960 | 4/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692679 | 0.91 | PDCD1 (0.41) | TRPV1ALDH1A1LMNAPDCD1CD274 | |
| SCHEMBL6027738 | 0.91 | ESRRG (0.40) | BCHEESRRBESRRGSLC6A5ITGB1 | |
| SCHEMBL6027475 | 0.90 | TRPV1 (0.37) | TRPV1EPHX2LTA4HSLC6A5LMNA | |
| SCHEMBL4694658 | 0.87 | ALDH1A1 (0.36) | TRPV1ALDH1A1LMNAPDCD1CD274 | |
| SCHEMBL6021934 | 0.87 | MEN1 (0.40) | TRPV1BCHEEPHX2LTA4HITGB1 | |
| SCHEMBL6027383 | 0.87 | OPRM1 (0.36) | BCHESLC6A5ITGB1ITGA4ITGB7 | |
| SCHEMBL4695551 | 0.86 | CNR2 (0.40) | TRPV1LMNAPDCD1CD274 | |
| SCHEMBL6022221 | 0.85 | BCHE (0.39) | TRPV1BCHEITGB1ITGA4ITGB7 | |
| SCHEMBL5247685 | 0.85 | OPRK1 (0.37) | TRPV1SLC6A5OPRM1OPRD1OPRK1 | |
| SCHEMBL5805321 | 0.85 | HDAC3 (0.40) | TRPV1BCHESLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723108-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | claimed |
| WO-2005087733-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | claimed |
| EP-1723108-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087733-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | disclosed |