Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 4/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695551 | 0.93 | CNR2 (0.40) | TRPV1CNR2GAAKDM4ELMNA | |
| SCHEMBL4691773 | 0.90 | KDM4E (0.41) | CNR2KDM4ELMNAHPGDHTR7 | |
| SCHEMBL4695176 | 0.90 | POLB (0.37) | CNR2KDM4ELMNAHPGDLTA4H | |
| SCHEMBL4692631 | 0.90 | ALDH1A1 (0.35) | TRPV1CNR2KDM4ELMNAERCC1 | |
| SCHEMBL6027362 | 0.90 | TRPV1 (0.39) | TRPV1LMNAOPRM1OPRD1OPRK1 | |
| SCHEMBL5805321 | 0.88 | HDAC3 (0.40) | TRPV1SLC6A5HTR7HTR1ADRD2 | |
| SCHEMBL6022221 | 0.85 | BCHE (0.39) | TRPV1ERCC1ERCC4HTR7HTR1A | |
| SCHEMBL6021982 | 0.85 | ALDH1A1 (0.39) | TRPV1GAALMNALTA4HEPHX2 | |
| SCHEMBL6021934 | 0.85 | MEN1 (0.40) | TRPV1GAALTA4HEPHX2 | |
| SCHEMBL6022017 | 0.84 | HTR1A (0.36) | TRPV1GAAHTR7HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723108-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2006-11-22 | — | — | EP | claimed |
| WO-2005087733-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2005-09-22 | — | — | WO | claimed |