Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689485 | 0.85 | CSNK1E (0.50) | MAPTHTTF2CSNK1ESMN1; SMN2 | |
| SCHEMBL4692605 | 0.85 | HTT (0.50) | ALDH1A1MAPTHTTCYP1A2CYP3A4 | |
| SCHEMBL4694678 | 0.84 | MAPT (0.45) | ALDH1A1TP53MAPTHTTF2 | |
| SCHEMBL4689950 | 0.83 | CRHBP (0.49) | F2RAB9APOLBKMT2A | |
| SCHEMBL4038318 | 0.81 | DNM1 (0.51) | F2CSNK1EPOLBTACR1 | |
| SCHEMBL4689625 | 0.80 | F2 (0.47) | ALDH1A1MAPTHTTF2CSNK1E | |
| SCHEMBL4038828 | 0.78 | BCHE (0.56) | F2CSNK1ENPC1RAB9AKMT2A | |
| SCHEMBL6877207 | 0.78 | MAPT (0.58) | ALDH1A1MAPTHTTCYP1A2CYP3A4 | |
| SCHEMBL4692657 | 0.76 | CSNK1E (0.48) | MAPTHTTF2CSNK1EPOLB | |
| SCHEMBL4694780 | 0.76 | CSNK1E (0.44) | ALDH1A1MAPTHTTF2CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692143-B1 | TRICYCLIC INDOLE HYDROXYETHYLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2008-11-12 | — | — | EP | disclosed |