Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gepefrine SCHEMBL30011768 | 0.86 | TAAR1 (0.61) | ADRB1MIFHTR2AADRA1AHTR2B | |
| Gepefrine SCHEMBL265538 | 0.86 | TAAR1 (0.61) | ADRB1MIFHTR2AADRA1AHTR2B | |
| Gepefrine SCHEMBL149774 | 0.86 | TAAR1 (0.61) | ADRB1MIFHTR2AADRA1AHTR2B | |
| Gepefrine SCHEMBL2562808 | 0.86 | TAAR1 (0.61) | ADRB1MIFHTR2AADRA1AHTR2B | |
| Gepefrine SCHEMBL2903938 | 0.85 | TAAR1 (0.59) | ADRB1MIFHTR2AADRA1AHTR2B | |
| Gepefrine SCHEMBL2903935 | 0.85 | TAAR1 (0.59) | ADRB1MIFHTR2AADRA1AHTR2B | |
| SCHEMBL4531632 | 0.84 | ALOX15 (0.55) | ADRB1MIFHTR2AADRA1AHTR2B | |
| SCHEMBL3067767 | 0.80 | ENPP2 (0.59) | ADRB1MIFHTR2AADRA1AHTR2B | |
| SCHEMBL647401 | 0.80 | OPRM1 (0.54) | ENPP2TAAR1DRD2DRD1CYP1A2 | |
| SCHEMBL19342844 | 0.79 | ADRB1 (0.50) | ADRB1MIFHTR2AADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1375489-B1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO (JP) | 2008-08-20 | — | — | EP | disclosed |
| CN-1301981-C | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO (JP) | 2007-02-28 | — | — | CN | disclosed |
| CN-1247553-C | 2-imino-1,3-thiazine derivs. | SHIONOGI & CO (JP) | 2006-03-29 | — | — | CN | disclosed |
| US-6916806-B2 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2005-07-12 | — | — | US | disclosed |
| US-20040116326-A1 | Medicinal composition containing 1,3-thiazine derivative | SHIONOGI & CO., LTD. (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1375489-A1 | MEDICINAL COMPOSITION CONTAINING 1,3-THIAZINE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |