Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | CASP6 | P55212 | 5/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763292 | 0.87 | HPGD (0.70) | HPGDCASP6OPRK1PDE4DGAA | |
| SCHEMBL6327688 | 0.86 | HPGD (0.74) | HPGDCASP6OPRK1PDE4DGAA | |
| SCHEMBL31422646 | 0.82 | HPGD (1.00) | HPGDCASP6OPRK1PDE4DGAA | |
| SCHEMBL143970 | 0.82 | HPGD (1.00) | HPGDCASP6OPRK1PDE4DGAA | |
| SCHEMBL11133610 | 0.79 | HPGD (0.62) | HPGDCASP6GAAKMT2AMEN1 | |
| SCHEMBL10398760 | 0.77 | OPRK1 (0.65) | HPGDCASP6OPRK1PDE4DGAA | |
| SCHEMBL16110543 | 0.77 | OPRK1 (0.65) | HPGDCASP6OPRK1PDE4DGAA | |
| SCHEMBL16456324 | 0.76 | HPGD (0.74) | HPGDCASP6GAAKMT2AMEN1 | |
| SCHEMBL4463146 | 0.76 | HPGD (0.74) | HPGDCASP6GAAKMT2AMEN1 | |
| SCHEMBL2982634 | 0.76 | GAA (0.59) | HPGDCASP6GAAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399155-B1 | SMALL MOLECULES USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASE | BOEHRINGER INGELHEIM PHARMA (US) | 2008-05-28 | — | — | EP | disclosed |
| US-6414153-B1 | TREATMENT OF INFLAMMATORY OR IMMUNE CELL-MEDIATED DISEASE OR CONDITION | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-07-02 | — | — | US | disclosed |