Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692980 | 0.86 | HPGD (0.69) | HPGDKMT2AMEN1DRD2DRD5 | |
| SCHEMBL143970 | 0.85 | HPGD (1.00) | HPGDKMT2AMEN1DRD2DRD5 | |
| SCHEMBL31422646 | 0.85 | HPGD (1.00) | HPGDKMT2AMEN1DRD2DRD5 | |
| SCHEMBL13167920 | 0.85 | HPGD (0.53) | HPGDKMT2AMEN1DRD2DRD3 | |
| SCHEMBL6763292 | 0.83 | HPGD (0.70) | HPGDKMT2AMEN1DRD2DRD3 | |
| SCHEMBL4463146 | 0.83 | HPGD (0.74) | HPGDKMT2AMEN1TNKSCASP6 | |
| SCHEMBL6765903 | 0.83 | HPGD (0.74) | HPGDKMT2AMEN1TNKSCASP6 | |
| SCHEMBL6328308 | 0.83 | HPGD (0.74) | HPGDKMT2AMEN1TNKSCASP6 | |
| SCHEMBL16456324 | 0.83 | HPGD (0.74) | HPGDKMT2AMEN1TNKSCASP6 | |
| SCHEMBL16110543 | 0.80 | OPRK1 (0.65) | HPGDKMT2AMEN1TNKSOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677368-B2 | 4-aryl substituted indolinones | SUGEN, INC. | 2004-01-13 | — | — | US | claimed |
| US-20030069297-A1 | 4-aryl substituted indolinones | SUGEN, INC. | 2003-04-10 | — | — | US | claimed |
| CN-104109160-A | Pyrrolo-N-heterocyclic compound, preparation method and medicinal application thereof | SHANGHAI JIESEN PHARMACEUTICAL CHEMISTRY TECHNOLOGY CO LTD | 2014-10-22 | — | — | CN | disclosed |
| US-6861418-B2 | 4-aryl substituted indolinones | SUGEN, INC. (US) | 2005-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069297-A1 | 4-aryl substituted indolinones | CDK5, CAMK4, TNK2 | HPGD 1764/4885KMT2A 1573/4885MEN1 4419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.