Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 13/20 | 0.54 |
| ▸ | EGFR | P00533 | 6/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | KIF5B | P33176 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.45 |
| ▸ | FLT4 | P35916 | 4/20 | 0.45 |
| ▸ | FLT1 | P17948 | 3/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421590 | 0.88 | TRPA1 (0.61) | TRPA1KDREGFRRETKIF5B | |
| SCHEMBL7145582 | 0.83 | TRPA1 (0.58) | TRPA1KDREGFRRETKIF5B | |
| SCHEMBL4421666 | 0.82 | TRPA1 (0.63) | TRPA1KDREGFRERBB2RET | |
| SCHEMBL4375675 | 0.82 | TRPA1 (0.63) | TRPA1KDREGFRERBB2RET | |
| SCHEMBL4420668 | 0.81 | KDR (0.61) | TRPA1KDREGFRERBB2RET | |
| SCHEMBL29195674 | 0.79 | CCR5 (0.51) | AURKB | |
| SCHEMBL7145586 | 0.79 | TRPA1 (0.53) | TRPA1KDREGFRRETKIF5B | |
| SCHEMBL4375838 | 0.79 | TRPA1 (0.62) | TRPA1KDREGFRRETKIF5B | |
| SCHEMBL21408242 | 0.77 | MET (0.58) | KDREGFRFGFR2MET | |
| SCHEMBL30216641 | 0.77 | MET (0.58) | KDREGFRFGFR2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296973-B1 | GUANIDINE DERIVATIVES OF QUINAZOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |