Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 13/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CCL5 | P13501 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693123 | 0.91 | CCR5 (0.50) | CCR5CCL5 | |
| SCHEMBL4694458 | 0.89 | CCR5 (0.53) | CCR5CCL5 | |
| SCHEMBL4694095 | 0.88 | CCR5 (0.51) | CCR5CCL5 | |
| SCHEMBL4693578 | 0.87 | CCR5 (0.53) | CCR5CCL5 | |
| SCHEMBL4691929 | 0.87 | CCR5 (0.48) | CCR5CCL5 | |
| SCHEMBL4694118 | 0.86 | KCNK3 (0.51) | CCR5L3MBTL1 | |
| SCHEMBL4693040 | 0.85 | CCR5 (0.51) | CCR5L3MBTL1 | |
| SCHEMBL4696366 | 0.84 | CCR5 (0.46) | CCR5CCL5 | |
| SCHEMBL4691536 | 0.84 | HCRTR1 (0.50) | CCR5CCL5 | |
| SCHEMBL4696493 | 0.83 | CCR5 (0.59) | CCR5CCL5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |