Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 12/20 | 0.51 |
| ▸ | CCL5 | P13501 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694458 | 0.92 | CCR5 (0.53) | CCR5CCL5 | |
| SCHEMBL4693123 | 0.90 | CCR5 (0.50) | CCR5CCL5 | |
| SCHEMBL4693284 | 0.88 | CCR5 (0.53) | CCR5CCL5 | |
| SCHEMBL4695271 | 0.88 | LMNA (0.53) | CCR5CCL5LMNA | |
| SCHEMBL4694257 | 0.88 | CCR5 (0.48) | CCR5CCL5 | |
| SCHEMBL4695293 | 0.88 | CCR5 (0.46) | CCR5CCL5 | |
| SCHEMBL4693578 | 0.88 | CCR5 (0.53) | CCR5CCL5 | |
| SCHEMBL4691536 | 0.87 | HCRTR1 (0.50) | CCR5CCL5 | |
| SCHEMBL4690556 | 0.86 | CCR5 (0.51) | CCR5CCL5 | |
| SCHEMBL4690515 | 0.85 | ALDH1A1 (0.47) | CCR5CCL5KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |