Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 1.00 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15103207 | 1.00 | TRPM8 (1.00) | TRPM8TRPV1MEN1NPC1RAB9A | |
| SCHEMBL22289417 | 1.00 | TRPM8 (1.00) | TRPM8TRPV1MEN1NPC1RAB9A | |
| SCHEMBL18552997 | 1.00 | TRPM8 (1.00) | TRPM8TRPV1MEN1NPC1RAB9A | |
| SCHEMBL4081078 | 0.92 | TRPM8 (0.85) | TRPM8TRPV1 | |
| SCHEMBL4088459 | 0.92 | TRPM8 (0.85) | TRPM8TRPV1 | |
| SCHEMBL4083810 | 0.92 | TRPM8 (0.85) | TRPM8TRPV1 | |
| SCHEMBL4088451 | 0.83 | TRPV1 (0.74) | TRPM8TRPV1 | |
| SCHEMBL11886519 | 0.83 | TRPV1 (0.74) | TRPM8TRPV1 | |
| SCHEMBL11886340 | 0.83 | TRPV1 (0.74) | TRPM8TRPV1 | |
| SCHEMBL11886341 | 0.83 | TRPV1 (0.74) | TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4268814-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | Universidad Miguel Hernández De Elche (ES) | 2023-11-01 | — | — | EP | claimed |
| EP-2614860-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | Universidad Miguel Hernández De Elche (ES) | 2013-07-17 | — | — | EP | claimed |
| EP-4268814-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | Universidad Miguel Hernández De Elche (ES) | 2023-11-01 | — | — | EP | disclosed |
| WO-2020160464-A1 | TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 (TRPM8) ANTAGONISTS AND RELATED METHODS | MARSHALL UNIVERSITY RESEARCH CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |
| US-10028920-B2 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2018-07-24 | — | — | US | disclosed |
| US-10028920-B2 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2018-07-24 | — | — | US | disclosed |
| US-10028920-B2 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2018-07-24 | — | — | US | disclosed |
| US-9901549-B2 | Method for treating vaginal dryness by administering transient receptor potential cation channel subfamily M member 8 (TRPM8) receptor agonists | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2018-02-27 | — | — | US | disclosed |
| US-9901549-B2 | Method for treating vaginal dryness by administering transient receptor potential cation channel subfamily M member 8 (TRPM8) receptor agonists | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2018-02-27 | — | — | US | disclosed |
| US-9901549-B2 | Method for treating vaginal dryness by administering transient receptor potential cation channel subfamily M member 8 (TRPM8) receptor agonists | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2018-02-27 | — | — | US | disclosed |
| US-20170071875-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C. (ES) | 2017-03-16 | — | — | US | disclosed |
| US-20150313854-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE (ES) | 2015-11-05 | — | — | US | disclosed |
| US-9095609-B2 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2015-08-04 | — | — | US | disclosed |
| US-9095609-B2 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2015-08-04 | — | — | US | disclosed |
| US-9095609-B2 | Ophthalmic composition comprising ws-12 and methods to treat xerophthalmia | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2015-08-04 | — | — | US | disclosed |
| US-20130245231-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C. (ES) | 2013-09-19 | — | — | US | disclosed |
| US-20130245231-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C. (ES) | 2013-09-19 | — | — | US | disclosed |
| US-20130245231-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C. (ES) | 2013-09-19 | — | — | US | disclosed |
| EP-2614860-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | Universidad Miguel Hernández De Elche (ES) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032209-A2 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (ES) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10028920-B2 | Methods for treating occular irritation involving tearing by administering modulators of TRPM8 | TRPM8, TRPM5, TRPM7 | TRPM8 1/4885TRPV1 8/4885MEN1 1937/4885 |
| US-20150313854-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885TRPV1 10/4885MEN1 2127/4885 |
| US-20170071875-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885TRPV1 10/4885MEN1 2127/4885 |
| US-20130245231-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DRY EYE | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885TRPV1 10/4885MEN1 2127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.