Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.86 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.86 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.86 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | CCND1 | P24385 | 3/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL334479 | 0.93 | ALDH1A1 (0.74) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| SCHEMBL6016496 | 0.93 | ALDH1A1 (0.74) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamaldehyde SCHEMBL28599267 | 0.93 | ALDH1A1 (0.90) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamaldehyde SCHEMBL25267814 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamic Aldehyde SCHEMBL159856 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamaldehyde SCHEMBL28377500 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamic Aldehyde SCHEMBL1866630 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamaldehyde SCHEMBL2203965 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamaldehyde SCHEMBL3442 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 | |
| Cinnamaldehyde SCHEMBL28377503 | 0.93 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1TRPA1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284734-B1 | ISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CUREGENICS LTD (IL) | 2008-05-21 | — | — | EP | disclosed |
| US-6949565-B2 | Protein kinase inhibitors | DEVELOGEN ISRAEL LTD. (IL) | 2005-09-27 | — | — | US | disclosed |
| EP-1284734-A4 | PROTEIN KINASE INHIBITORS | PEPTOR LTD (IL) | 2004-03-10 | — | — | EP | disclosed |
| US-20040019077-A1 | Heterocyclic imines such as N1-(8-sulfonamide-5-isoquinoline)-N2-(3,3-diphenyl-2-propenyl) -ethylenediamine, used for prophylaxis and diagnosis of cancers, diabetes, cardiovascular and nervous system disorders, autoimmune diseases or obesity | CUREGENICS LTD. (IL) | 2004-01-29 | — | — | US | disclosed |
| EP-1284734-A1 | PROTEIN KINASE INHIBITORS | Peptor Ltd. (IL) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001091754-A1 | PROTEIN KINASE INHIBITORS | PEPTOR LTD. (IL) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019077-A1 | Heterocyclic imines such as N1-(8-sulfonamide-5-isoquinoline)-N2-(3,3-diphenyl-2-propenyl) -ethylenediamine, used for prophylaxis and diagnosis of cancers, diabetes, cardiovascular and nervous system disorders, autoimmune diseases or obesity | CHKB, MAP4K2, PKN2 | ALDH1A1 3992/4885LMNA 1813/4885MAPK1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.