Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4689933 | 0.87 | MALT1 (0.43) | KDM4EGAASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4693294 | 0.87 | PDE10A (0.42) | KDM4EGAASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4693056 | 0.87 | TP53 (0.44) | SMN1; SMN2CCR3HCRTR1HCRTR2MAPT | |
| SCHEMBL4691538 | 0.84 | CHRNB2 (0.44) | KDM4EGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4691640 | 0.82 | MAPT (0.54) | KDM4EGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3282227 | 0.82 | CCR5 (0.51) | KCNH2 | |
| SCHEMBL4693802 | 0.81 | MEN1 (0.46) | SMN1; SMN2ALDH1A1MAPTDRD3 | |
| SCHEMBL4695974 | 0.81 | ALDH1A1 (0.43) | KDM4EGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4692889 | 0.81 | MAPT (0.45) | KDM4EGAASMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL4693334 | 0.81 | ALDH1A1 (0.45) | KDM4EGAASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |