Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.53 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694151 | 0.86 | NTRK1 (0.55) | NTRK1IGF1RPIM1CCNA2CDK2 | |
| SCHEMBL4696455 | 0.83 | NTRK1 (0.64) | NTRK1PIM1CCNT1 | |
| SCHEMBL56866 | 0.80 | NTRK1 (0.52) | NTRK1SMN1; SMN2LMNACCNT1MEN1 | |
| SCHEMBL4694035 | 0.76 | NTRK1 (0.54) | NTRK1IGF1RPIM1 | |
| SCHEMBL4693854 | 0.74 | NTRK1 (0.59) | NTRK1FLT3 | |
| SCHEMBL4695287 | 0.71 | NTRK1 (0.62) | NTRK1IGF1RCCNA2CDK2CCNA1 | |
| SCHEMBL4698140 | 0.70 | NTRK1 (0.66) | NTRK1IGF1RLMNA | |
| SCHEMBL4750903 | 0.70 | NTRK1 (0.79) | NTRK1FLT3 | |
| SCHEMBL4695215 | 0.69 | NUAK1 (0.61) | NTRK1IGF1R | |
| SCHEMBL3766966 | 0.68 | NTRK1 (1.00) | NTRK1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |