Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | CCL5 | P13501 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 4/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282872 | 1.00 | DRD2 (0.36) | DRD2DRD4DRD3SMOCCKBR | |
| Cyclopentane SCHEMBL4691240 | 0.83 | CCR5 (0.48) | MAPK1CCR5 | |
| SCHEMBL4690865 | 0.81 | CCR5 (0.46) | CCL5MAPK1MAPTCCR5SLC9A1 | |
| SCHEMBL13326752 | 0.79 | CCR5 (0.61) | CCR5 | |
| SCHEMBL5421969 | 0.79 | CCR5 (0.61) | CCR5 | |
| SCHEMBL4694250 | 0.77 | CCR5 (0.44) | CCL5MAPK1MAPTCCR5ALDH1A1 | |
| SCHEMBL4692842 | 0.76 | GBA1 (0.43) | CCR5ALDH1A1 | |
| SCHEMBL4691491 | 0.75 | FPR2 (0.50) | ALDH1A1 | |
| SCHEMBL4693317 | 0.75 | EIF4A3 (0.49) | CCL5MAPK1MAPTCCR5ALDH1A1 | |
| SCHEMBL4690883 | 0.75 | NR1H4 (0.41) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |