Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 14/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694867 | 0.92 | CCR5 (0.34) | CCR5KCNH2 | |
| SCHEMBL4690445 | 0.92 | EPHX2 (0.38) | CCR5KCNH2 | |
| SCHEMBL4691722 | 0.90 | CCR5 (0.39) | CCR5USP30KCNH2UBE2MDCUN1D1 | |
| SCHEMBL4690611 | 0.89 | CCR5 (0.37) | CCR5KCNH2UBE2MDCUN1D1 | |
| SCHEMBL4694952 | 0.89 | CCR5 (0.37) | CCR5KCNH2UBE2MDCUN1D1 | |
| SCHEMBL4691638 | 0.88 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4694148 | 0.88 | MAPT (0.36) | CCR5KCNH2UBE2MDCUN1D1 | |
| SCHEMBL4691621 | 0.88 | CCR5 (0.35) | CCR5KCNH2 | |
| SCHEMBL4690740 | 0.88 | CCR5 (0.42) | CCR5KCNH2 | |
| SCHEMBL4694419 | 0.87 | CCR5 (0.36) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |