Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 10/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694359 | 0.92 | CCR5 (0.34) | CCR5KCNH2 | |
| SCHEMBL4753854 | 0.89 | CCR5 (0.34) | CCR5KCNH2 | |
| SCHEMBL4690445 | 0.88 | EPHX2 (0.38) | CCR5KCNH2 | |
| SCHEMBL4690306 | 0.88 | CCR5 (0.38) | CCR5KCNH2TRPV1 | |
| SCHEMBL4691638 | 0.86 | CCR5 (0.37) | CCR5KCNH2 | |
| SCHEMBL4691722 | 0.86 | CCR5 (0.39) | CCR5KCNH2TP53MAPTSMN1; SMN2 | |
| SCHEMBL4694864 | 0.86 | CCR5 (0.40) | CCR5KCNH2TRPV1PROKR1TP53 | |
| SCHEMBL4690740 | 0.86 | CCR5 (0.42) | CCR5KCNH2 | |
| SCHEMBL4690611 | 0.85 | CCR5 (0.37) | CCR5KCNH2MAPT | |
| SCHEMBL4694952 | 0.85 | CCR5 (0.37) | CCR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |