Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692947 | 0.94 | CPS1 (0.41) | P2RX7HCRTR1HCRTR2ALDH1A1KCNK3 | |
| SCHEMBL4692704 | 0.93 | HCRTR1 (0.49) | P2RX7HCRTR1HCRTR2ALDH1A1AVPR2 | |
| SCHEMBL4692715 | 0.92 | HCRTR1 (0.43) | P2RX7HCRTR1HCRTR2ALDH1A1MEN1 | |
| SCHEMBL4690682 | 0.91 | P2RX7 (0.44) | P2RX7HCRTR1HCRTR2ALDH1A1AVPR2 | |
| SCHEMBL4692110 | 0.90 | HCRTR1 (0.51) | P2RX7HCRTR1HCRTR2HSD11B1ALDH1A1 | |
| SCHEMBL4692994 | 0.90 | AVPR2 (0.42) | ALDH1A1AVPR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4695322 | 0.90 | TSHR (0.46) | ALDH1A1AVPR2RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4689475 | 0.89 | SMN1; SMN2 (0.39) | P2RX7HCRTR1HCRTR2ALDH1A1MEN1 | |
| SCHEMBL4694086 | 0.89 | TSHR (0.40) | ALDH1A1AVPR2RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4693334 | 0.89 | ALDH1A1 (0.45) | P2RX7ALDH1A1KMT2AAVPR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |