SCHEMBL4694649

SCHEMBL4694649

COC(=O)c1cc(C(=O)NCCc2ccccc2)cc(N(C)S(C)(=O)=O)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 1/20 0.55
KDM5B Q9UGL1 1/20 0.54
NPC1 O15118 8/20 0.52
RAB9A P51151 8/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
ALDH1A1 P00352 1/20 0.52
TP53 P04637 1/20 0.52
MGLL Q99685 1/20 0.49
LMNA P02545 2/20 0.48
HDAC3 O15379 1/20 0.48
HDAC4 P56524 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL475666 0.90 MCHR1 (0.58) MCHR1KDM5BNPC1RAB9ASMN1; SMN2
SCHEMBL3645315 0.88 MCHR1 (0.56) MCHR1NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL4747063 0.82 KDM5B (0.56) KDM5BNPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL4749720 0.81 TP53 (0.50) NPC1RAB9ASMN1; SMN2ALDH1A1TP53
SCHEMBL3646617 0.80 BACE1 (0.66) BACE1BACE2
SCHEMBL3348673 0.80 RAB9A (0.65) KDM5BNPC1RAB9ASMN1; SMN2MGLL
SCHEMBL3644965 0.80 BACE1 (0.67) BACE1BACE2
SCHEMBL3646488 0.80 LMNA (0.55) NPC1RAB9ASMN1; SMN2ALDH1A1LMNA
SCHEMBL3643931 0.79 CA1 (0.59) NPC1RAB9ABACE1
SCHEMBL475760 0.79 KDM4E (0.56) NPC1RAB9ASMN1; SMN2ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1871739-A1 COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2008-01-02 EP disclosed
WO-2006110668-A1 COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF COMENTIS, INC. (US) 2006-10-19 WO disclosed