Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750119 | 0.88 | SMN1; SMN2 (0.50) | TP53PKMSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL475760 | 0.83 | KDM4E (0.56) | TP53SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL3595760 | 0.82 | L3MBTL1 (0.51) | TP53PKMSMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL4694649 | 0.81 | MCHR1 (0.55) | TP53SMN1; SMN2LMNAALDH1A1BACE1 | |
| SCHEMBL4749719 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKDM4EMEN1KMT2A | |
| SCHEMBL3855873 | 0.78 | KDM4E (0.44) | TP53SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL7868931 | 0.77 | KDM4E (0.51) | TP53SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL165562 | 0.77 | KDM4E (0.51) | TP53SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL13229602 | 0.77 | LMNA (0.50) | SMN1; SMN2LMNAL3MBTL1KDM4EMEN1 | |
| SCHEMBL3446852 | 0.76 | L3MBTL1 (0.50) | TP53SMN1; SMN2LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119772-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |